2014年1月25日星期六

Reduction of Cholesterol by Alternative Therapies

Abstract

Although synthetic chemicals and pharmacological agents are being used for the treatment of cardiovascular disease in the western world, there now appears to be a cultural and philosophical shift toward Eastern Medicine and many patients are increasingly using alternative approaches for prevention and therapeutic purposes. This brief review summarizes the experimental and clinical evidence of some functional foods, herbal products and medicinal plants for improving plasma HDL cholesterol, LDL cholesterol, triglycerides and glucose levels, as well as reducing oxidative stress. In addition, the potential of acupuncture and Yogic meditation are discussed as emerging approaches for reducing cardiovascular disease risk factors. The available evidence indicates that several functional foods, herbal products and medicinal plants exert lipid-lowering and hypoglycemic actions, as well as exhibit antioxidant properties; however, a great deal of research work and extensive clinical trials are needed to establish their use in medical practice.

Introduction

The accumulation of lipids within arteries remains the initial stimulus for the pathogenesis of atherosclerosis; however, oxidative stress is also considered to play a critical role in this process.[1]Several lipid-lowering drugs, such as statins, are used as the first-line therapy in hypercholesterolemia.[2]Statin monotherapy is generally well tolerated; however, a low frequency occurrence of myopathy and asymptomatic increase in hepatic transaminases have been reported.[2] In addition, since statins are prescribed on a long-term basis, drug–drug interactions are possible, since many of the patients that receive statins may also be prescribed other medications for concomitant conditions.[2] In a study on cholesterol-lowering statin drugs (all types) involving 150,000 postmenopausal women, aged 50–79, it was found that statin intake was linked to a 48% increase in the risk of developing diabetes.[3]Furthermore, statin use was linked to an even higher risk of diabetes in Hispanic and Asian women, at 57 and 78% higher, respectively, and women who were not overweight (and thus not at risk of developing diabetes) were at a similar risk as women who were overweight for developing diabetes. Interestingly, it has been suggested that while statins are of benefit for people with known heart disease, they may be of no benefit to individuals without known heart disease and are attempting to control their blood cholesterol levels.[4]
On the other hand, the use of herbal and medicinal plant products has gained popularity as preventive or therapeutic agents for cardiovascular disease (CVD). Herbs are generally defined as any form of plant or plant products that are regarded as food or natural health products. Herbal supplements have been used for medicinal purposes for thousands of years in the East, particularly the Ayurvedic system and the Chinese medicine, and have recently become popular among consumers in the west.[5] It should be mentioned that Ayurveda is derived from two Sanskrit words, namely 'Ayus' and 'Veda,' meaning life and knowledge, respectively. It is a holistic system that focuses on the body, mind and conscious. Ayurvedic treatment consists of the use of herbal preparations and emphasizes the practice of yoga and meditation.[6] The traditional Chinese medicine is based on 'Zheng' system for the control of overall function of the human body and emphasizes the use of acupuncture and that practice of qigong.[7] Herbal medicines including traditional Chinese and Ayurvedic medicines are considered to be cost-effective in the management of disease and this alternative form of medical practice differs in philosophy from the modern medicine, and is known to play an important role in health maintenance.[8]
In the holistic approach to health care, both the disease and the underlying causes are being controlled through physical, mental, social and spiritual well-being. Although these alternative therapies are gaining popularity, several issues regarding safety and efficacy of herbal medicines remain to be addressed.[5,9,10] Since elevated levels of plasma total cholesterol, LDL cholesterol (LDL-C), triglycerides (TGs) and glucose are well-known risk factors for coronary artery disease (CAD), this brief review is focused on some of the alternative therapies for improving blood lipid profile and glucose levels. While it has been argued that it is not only native LDL that contributes to atherosclerosis, but the amount of oxidized LDL that is a key contributor to atherosclerosis,[1] this article will therefore also discuss the possible antioxidants effects of functional foods, herbal products and medicinal plants. In view of the role of diabetes as a major risk factor for CVD, this article will also discuss the hypoglycemic and hypolipidemic effects of these therapies during diabetes.
The selected therapies are based on the availability of clinical evidence on efficacy, with respect to improvements in the plasma profiles of total cholesterol, HDL cholesterol (HDL-C), LDL-C (native and oxidized forms) and TGs, as well as glucose-lowering and antioxidant effects (Figure 1). These natural products deserve further work to isolate and characterize their constituents for the development of novel and more effective agents. A consideration for acupuncture, as well as yoga, is also presented as emerging alternative approaches in preventing/treating CVD.

Figure 1.

Putative beneficial effects of functional foods, medicinal plants and herbal products on markers of cardiovascular disease.



2014年1月20日星期一

Synthroid vs. Tirosint

http://bbs.wenxuecity.com/thyroid/263514.html

我在41岁时,有过一次甲状腺发炎,吞咽困难,发烧,几天后逾越,做过同位素检查,无异样病变,但是从这以后,便开始了我十几年与甲状腺低下抗争的漫漫的路程。
甲状腺低下是一种内分泌失调疾病,症状是新陈代谢降低,精神不振,怕冷,反应迟钝,体重增加,检测指标是TSH(甲状腺刺激荷尔蒙)高于4.5 这种疾病很常见,在生育以后的妇女中高达13%,治疗方案是吃Synthroid,  补充甲状腺,要终身吃药。开始几年,我可以吃Synthroid,没有什么反应,医生将剂量调到合适,控制TSH在正常值内。
到我过了50岁后,开始有了睡眠问题,Synthroid吃下后太兴奋,难以入睡,我便停了药,睡眠好转,但是TSH指标上升,不能不理会。医生认为Synthroid不会造成睡眠障碍,开一些安眠药给我吃,吃安眠药会成瘾,自己心里有阴影。 这种情况持续了好几年,我的TSH高到了17,家庭医生很不同意我停药,虽然我的症状还不明显。我也到国内看过内分泌专科医生,结论一样,不能停药,睡眠问题另外解决,可以用些五味子等中药,但是效果较慢,不能解决根本问题。那段时间其实我的状况不好,睡眠和甲状腺指标均不好。
到了2009春,工作压力很大,回国一次,家中照顾老母亲的保姆老是搞不定,加上中美来回两边倒时差,睡眠很差,体重持续下降,思想无法集中,我意识到自己出现了忧郁症症状,并且伴有手发抖的现象,我觉得不能再服用Synthroid了,验血后,TSH指标在6左右,虽然还是高了些,但是我的身体长期在甲状腺低下的状态,已经不适应接近正常的水平了,这时我的专科医师同意我停了Synthroid,观察一段时间。另外她提议我验维他命D,若是维他命很低的话,是会造成浑身无力的感觉,可以吃大剂量处方维他命D。验出来的D非常低,医生给我开了药。后来,我请教了在制药公司工作的朋友,她告诉我,最新研究发现,甲状腺问题加上维他命D低下,有可能激发忧郁症。我与此位朋友相知多年,她说我不像会得忧郁症的人,这条消息给了我一些帮助,当时自己一直在“我怎么会变成这样?”的怪圈中走不出来,关于这一段心路历程,我纪录在了“失而复得从忧郁症中走出来”一文中。
自知甲状腺终究是个问题,等我走出了忧郁症,睡眠也变好后,我开始吃一些Synthroid,反应大,总吃不到医生要求的剂量。 2010年中开始,体重直线上升,四个月中增了15磅,中老年妇女的这段时期是比较难过的,我也搞不清是甲状腺问题还是更年期发胖,验血后吓一跳,TSH高到55,赶紧去看专科医师,她给我换了一个药,叫作 Tirosint50毫微克,她认为还是不够,但是让我先服用,两个月后再去看。我吃了没有反应,睡眠正常,也没有过于饥饿的感觉,心里障碍解除了,我认认真真吃了两个月,心里非常感谢这位专科医师。我在与忧郁症抗争时,体会到药是否对路太重要了,也感到找一位高明的医师的必要,所以这一次也是认真对待。两个月后,TSH降至9,医师继续加剂量,到达75毫微克,但是让我看身体反应,不适应的话,可以回到50毫微克。我自己调整一下,大概是三天吃75毫微克,一天吃50毫微克,人感到轻松些了,于是加强锻炼,节制饮食,体重开始慢慢下降,自我感觉良好。
又过了6周,我的TSH降到3.0,正常范围是0.45 – 4.5 这是十几年以来第一次降到正常值,我向医师表示由衷的钦佩和感谢,医师也很高兴,她说两个药的主要成分是一样的,填料不同。但是就是这个填料不被我的身体接受,才让我受了那么多年的痛苦。医师说我可以保持我的交换服药法,只需四个月以后去看她,她还说,TSH降到1--2,人会感到轻松有活力。
告别医师,我心情愉快地回家,几年磨练,总算修得正果,以后不用老是去看医生,真是一件好事。人的新陈代谢机能恢复后,会影响到各方面,譬如,我不再那么怕冷,不是那么老是觉得口渴,头发脱落减少了,体重略下降,人感到轻松了,还有的指标照理与甲状腺无关,但是我的血压,胆固醇,血脂都变好了,其中胆固醇十几年来第一次降到200以下。现在下了班,我还可以做饭,晚饭后整理花园,然后走半小时。我看待事物也正面积极了,虽然生活中总有不顺利的事,但是有了健康,不就是最大的幸事么?这次的甲状腺指标恢复正常,还真让我兴奋了好几天。
在经过了这漫长的过程,有几点体会,
  • 第一是我们要尊重科学,指标不好也许还没有反应到身体其它部分,但是长期下去是不行的,后果严重。甲状腺低下在中国国内的重视还不如西方国家,忠告有同样疾病的同胞,一定要积极对待;
  • 第二,美国的医生水平还是不错,敬业而且尊重病患的感觉,即使我讲得不对,他们也不会训斥讥笑你,很是和蔼可亲。像Synthroid这个药,是一个很成熟的药,对绝大部分患者都适用,若是在国内,医生不会听得进我的抱怨,但是我的医生配合我的需要换了新药。在美国医学院,专门教授“医患关系”课程,医生提供服务,病人是他们的市场,这比在国内看病受气要好很多;
  • 第三,自己要配合,要钻研,我有一次的TSH指标非常高,后来我听了电台中的医学讲座,发现吃Synthroid时,四小时之内不能服钙片,我改正后,指标马上低了下来,后来又发现,其实这一点标在药瓶上,因为字体小,是我忽略了。我也在网上看病友的文章,发现也有人与我一样,不能吃Synthroid,病友们鼓励你将感觉和建议和医生交流,有人甚至因为医生听不进建议,将医生炒了鱿鱼,另外找了一个。

在此将自己的经历写出来,希望能惠益他人,不必花那么大的代价,走那么曲折的路,才找到合适的治疗方案。

======================
青竹叶回复悄悄话回复nightrose的评论:
说得好,当时我的家庭医生没有让我转去看专科医生,耽误了。 至于我目前服用的Tirosint,好像是新近才批准上市的,2009年时专科医师提起过“Armor”。这一类药的选择并不多



nightrose回复悄悄话楼主刚得病时就应该多查查医学资料,看看各路专家对用药的建议。我也得过急性甲状腺发炎,最初医生也没有确诊,在瞎猜我是不是扁桃体发炎等等。我在网上查过资料后去建议医生作化验,才诊断出来。治疗过程中我也不断查资料,确保知道自己的病是怎么一回事。
网上有各种甲状腺激素口服药的明确比较。一种药不行应该试另一种,怎么能等好几年?

2014年1月5日星期日

Second Opinion of RAI

I had RAI after my TT in July and didn't have very many issues with it at all. I did it in isolation at the hospital and it was very effective. The only real side effect was my taste is off a bit and I was tired for a bit afterwards but nothing more than anything else. I can't imagine any thyroid oncologist not recommending RAI but it's always good to check out all the options especially if you are young. I'm searching for a second opinion doc and am set up to see Dr. Kenneth Ain at Univ of KY. He wrote the book so many of us have lived by. After doing all my research and getting care of Moffitt Cancer Center that is world renowned I have decided Dr Ain is the best choice for me and I've gotten good feedback on this site about him. He ONLY does thyroid and his wife is also on endocrinologist only specializing in thyroid cancer research. Google him and you can also email him and he actually replies!
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This is just to offer another perspective. Unless he has changed his mind recently, Dr. Ain seems to give every low risk patient (except those with tumors under 1 cm), an empiric dose of 100 mCi. Most of the research is now recommending against this practice, as studies show that it does not benefit low risk patients and may even harm them. Many of things that doctors recommended in the past about RAI have recently been shown to be incorrect. The trend is for less RAI or none.
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Hi: Here's a new study which found that RAI treatment doesn't affect the recurrence rate for patients with microscopic capsular invasion:

http://onlinelibrary.wiley.com/doi/10.1111/ajco.12159/abstract;jsessionid=C 8E8BD1F53EC125912D7470200CA70B0.f03t04?deniedAccessCustomisedMessage=&userI sAuthenticated=false

--------------
Hi,

I'm about two months out from TT with follicular cancer surgery. I live in Marin County in Northern Ca. I tried to get to see Orloff at UCSF, but didn't want to wait forever (it would have been months). My endo is Eric Buxton, but he is also hard to get an appointment with. Here is what I have discovered. 
UCSF still uses RAI as there "go to" treatment (no matter what). Mayo and other places have backed off and only use it sparingly. I have decided not to have it unless the cancer has spread (which there is no sign of happening). I had a great surgeon, Dr. Agbayani, in Greenbrae. But, the endo makes the decision about an RAI recommendation. Right now, they would have to convince me I was going to die tomorrow, before I would do it. And, they don't do in the hospital here, so I would have to board my cats, change my whole life, and perhaps have some not so great side effects. Also, I'm 68 and don't want to put my liver and kidneys through the stress of getting rid of all that radioactive iodine. And since my cancer came from radiation as a child, it seems crazy to do more of it to get rid of it. Second opinions are great, if you can get into see a good endo. I do recommend Dr. Buxton, but I don't know when he would see you. But, even if you would have to wait, it might be worth it before having more treatment. Sending prayers and healing thoughts.

2013年12月30日星期一

甲状腺切除手术 (THYROIDECTOMY)




Notes
Bad reactions to the anesthesia


THYROIDECTOMY 

Your Body

The goal of a thyroidectomy is to treat your condition by removing all or part of thethyroid gland. This operation is an excellent way to treat, or begin treating, several thyroid problems.

The thyroid is in the front part of your neck, just below your voice box (larynx). It's shaped a little like a butterfly. The butterfly's wings are the right and left lobes. The lobes wrap around your windpipe.

Nerves that control your vocal cords and voice box run alongside your windpipe. On the back side of your thyroid are the parathyroid glands. They control calcium levels in your body.
Bean-shaped things called lymph nodes carry a fluid called lymph as it moves through your lymphatic system, which runs all over your body.
What does the thyroid gland do? 
The thyroid uses iodine from your blood to make a hormone that controls how your body uses energy (or your metabolism). So it helps control things like how many calories you burn, your body temperature, and menstrual cycles (or when you get your period).
Your thyroid hormone level needs to be balanced so your body works as it should. Too much or too little thyroid hormone in your blood can throw your system out of balance and cause all kinds of problems.
You can live without a thyroid gland.
Even if your entire thyroid gland is removed, taking daily medication can get thyroid hormone into your system. In fact, you may already take medicine to keep your thyroid hormone level in a healthy range.

Your Condition

Some thyroid conditions are more likely to need surgery than others. But some of the most common conditions that need to be treated with this operation are:
  • Nodules (lumps)
  • Goiters
  • Hyperthyroidism
  • Thyroid cancer
Nodules
Nodules are lumps inside the thyroid gland. They're pretty common, and anyone can get them. Most of the time, nodules don't cause any problems. And if a harmless nodule is found, your doctor may decide to just leave it alone.
But you may need surgery if a nodule is:
  • Getting bigger
  • Pressing against structures in your neck (like your windpipe)
  • Your doctor thinks it may be thyroid cancer
If you have a nodule, before the operation, your doctor will most likely do something called a fine needle aspiration (also called an FNA or biopsy). In fact, you may have already had this.
Usually, a fine needle aspiration is done to remove a few cells so they can be looked at under a microscope to make sure cancer isn't there.
Goiter
When the entire thyroid gland gets bigger it's called a goiter. Like nodules, goiters don't always have to be removed. But if a goiter is causing problems with swallowing or breathing, or if it's big and your doctor thinks it should come out, surgery may be done to remove it.
Doctors often don't know of any one cause for goiters. But they may be caused by a combination of things, including:
  • Family history
  • Exposure to radiation at some point in your life
  • You don't get enough iodine
  • The thyroid is making too little or too much thyroid hormone
HypothyroidismWhen the thyroid makes too little hormone, it's called hypothyroidism. Surgery is notneeded to treat this.
Hyperthyroidism
When it makes too much hormone it's called hyperthyroidism. Surgery may be done for this. Hyperthyroidism speeds up your metabolism and causes your body to use energy too fast, and this can make you feel jittery, irritable, lose weight, or have trouble sleeping.
The thyroid isn't always removed to treat hyperthyroidism. But when medication or other things like radioactive iodine treatments don't work to control hyperthyroidism, all or part of the thyroid may need to be removed.
Thyroid cancerAs you know, our bodies are made up of billions of cells. In a healthy body, cells grow, divide, and eventually die. And as old cells die off, they're constantly replaced by new ones. Cancer happens when abnormal cells continue to multiply. And a lump of tissue called a tumor can form.
The most common, and most treatable, type of thyroid cancer is something calledpapillary thyroid carcinoma. This kind of cancer tends to grow slowly, and usually is NOT life threatening. In fact, it has a very high cure rate. But there aren't many things scarier than cancer, no matter how treatable it is. So if you've been diagnosed with thyroid cancer, talk with your doctor about the type you have.

Before Surgery

Before surgery, you'll probably have a few more tests. You'll most likely have a physical exam that may include things like:
  • A blood test
  • Imaging tests like an ultrasound or CT scan
  • An EKG to check out your heart
It's also very important for your surgeon to learn about your overall health and your health history. And it's up to you to fill her in. Think of yourself as a key member of your healthcare team. When you give your doctor the information she needs, you increase your chance for success.
Let your surgeon know if:
  • You have any health conditions
  • You're allergic to anything (like penicillin or latex)
  • You or anyone in your family has ever had a bad reaction to anesthesia
  • There's any chance at all you may be pregnant
For your safety, make a list of everything you take. Be sure to include:
  • All prescription and over-the-counter drugs
  • Herbal supplements
  • Vitamins
  • Recreational drugs
You may need to get some medications out of your system in the weeks before surgery. 
For instance, your doctor may ask you to temporarily stop taking anything that can increase the risk of bleeding. This includes things like:
  • Aspirin
  • Anti-inflammatory drugs like Advil®, Motrin®, or any arthritis medication
  • Herbs like Ginkgo biloba
If you take a blood thinner like warfarin (also called Coumadin®) or drug called Plavix®, you'll need to talk to the doctor who put you on this drug to find out exactly what to do. But do not stop taking this kind of medication on your own. Your doctor needs to help you do this safely.
For a complete list of what to stop taking, and when, ask your doctor.

It's also important to know which medications you should KEEP taking. 
If you take medication now for things like high blood pressure, make sure you talk with your doctor about this.
Support
It's a good idea to ask a family member or a friend to be there with you for comfort and support. Think of this person as your partner in care. Doctors and nurses like to have one "go to" person for all communication. He or she should be able to speak up for you, ask questions, and give information about your health. Be sure to introduce this person to your doctors and your nurses so they know it's OK to share your health information with them.
The night before surgery
One thing that's VERY important, do NOT eat or drink anything after midnight.
If there's anything in your stomach and you throw up during the operation, it can be very dangerous. So make sure your stomach is EMPTY, or your surgery may need to be rescheduled.
That said, if your doctor says it's OK to take some or all of your regular medications on the morning of surgery, just take it with a sip of water.

 

Your Procedure

Your surgeon will have a specific plan for your operation and recovery. But this will give you a general sense of how surgery will go.
First, an IV line will be placed in your hand or your arm. This is so you can receive antibiotics, medication, and fluids.
Then you'll go to the operating room. When you get there, you may be connected to:
  • Monitors that measure your blood pressure and heart rate
  • A pulse oximeter will be placed on your finger to measure the oxygen in your blood
  • Compression boots to help lower the risk of blood clots in your legs
Anesthesia
Then they'll start your anesthesia, which can be given a couple of ways.
You may have a combination of medicine to numb your neck, and medication that will make you very drowsy. This is called conscious sedation. The medicine won't put you to sleep completely. But you probably won't remember anything that happens during surgery.
General Anesthesia
Many times, this surgery is done under general anesthesia, which puts you into a deep sleep, so you're completely out.
  1. An oxygen mask is placed over your mouth and nose, and you'll be asked to take deep breaths.
  2. Then you'll get the anesthesia through your IV. The medication may sting or burn a little bit when it goes in, but don't worry, that's normal.
  3. Very quickly, you'll fall asleep. After this, you really won't remember anything about the procedure.
  4. Once you're asleep, a tube is placed in the back of your throat or down your windpipe to help you breathe. You won't feel the tube going in or coming out. But when you wake up, your throat may feel a little sore. And even though this operation is on your neck, the tube won't get in your surgeon's way during the operation.
The Procedure
When everything is ready, surgery can begin. It usually takes anywhere from 1 to 3 hours.
  1. Your surgeon will start by making a 2 to 4 inch opening in your neck.
  2. Then she'll spread the skin and muscle to see the thyroid gland.
  3. Next she'll carefully remove part of the thyroid. But if she needs to, your surgeon may remove the entire thyroid gland. How much of the thyroid is removed depends on your condition and what your surgeon thinks is best.
  4. If your operation is for thyroid cancer, your surgeon may remove a few lymph nodes as well. If cancer cells spread, they often travel through the nodes first. So your surgeon may remove a few or all of the nodes to see if cancer has spread to them.
  5. Then the cut is closed with stitches that go under the skin and surgical tape. And the wound is covered with a small bandage.
  6. A tube may be placed in your neck to drain any fluid that may collect there after surgery. If a tube is placed, it will most likely be taken out before you go home.
     

After Surgery

After surgery, expect to feel groggy and a little out of it. If you feel sick to your stomach or have the chills, just ask your nurse to help you get comfortable.
In recovery
You'll be hooked up to some monitors and your IV line for medication and fluids. After a couple of hours, a nurse will help you get up and walk. Moving around can help prevent blood clots from forming in your legs and helps you regain strength.
Most people are surprised by how well they feel right after surgery. In fact, a lot of people are able to walk around and eat normally the same day as their operation.
Going home
Some people go home the same day as their surgery. But many people stay for a night. Once your doctor thinks you're ready, you can go home. Just make sure you have someone to drive you home and stay with you.
In fact, you may not be able to drive for a while. If you have any questions about when it's safe for you to drive again, ask your doctor.
When I get home, will I be in a lot of pain?
Many people say the pain isn't too bad. But for the first few days after surgery you may have:
  • Pain, swelling, or bruising around your wound
  • A sore throat
  • Muscle aches or stiffness in the back of your neck and in your shoulders
Your doctor will prescribe pain medication if you need it. But some people only feel like they need to take over-the-counter drugs like Tylenol® for their discomfort. In fact, some people don't need to take any medication at all. Just make sure you understand your doctor's instructions on how and when to take any medications.
Bathing
  • Your doctor may tell you not to shower for a day or so after surgery.
  • To prevent infection, she'll most likely tell you not to go swimming or take baths until your cut is healed over.
  • After you get the OK to shower, just pat your cut dry with a towel when you're done.
If you have any questions about this, ask your doctor.
Returning to work and other activities
You should be able to return to work in about a week. But it could be sooner or later. It just depends on how well you feel and what kind of job you have.
You'll most likely feel good enough to do many of your normal activities in a few days to a week. Just don't push yourself too hard in the first couple of days.
One thing you should do is move your neck from side to side. Rolling your shoulders is good, too. Gentle stretches like these should help prevent stiffness.
Of course, if you have any problems during recovery, please call your surgeon.

Call right away if you have:
  • A fever of 101°F or higher
  • Severe pain that does NOT get better with medication
  • Sudden shortness of breath or chest pain
  • Bleeding that soaks your bandage
  • Pain, swelling, or fluid leaking from your cut
  • Difficulty breathing or you can't swallow food or liquid
Also call if you have:
  • Muscle twitches or cramping in your feet, hands, or face
  • Numbness around your mouth
  • Tingling in your fingers, toes, or lips
It's normal to have MILD numbness and tingling in these areas. But if it's severe, call your doctor.
Or call if you experience anything unusual. If something just feels wrong, let your doctor know.
Thyroid replacement therapy
Depending on how much of your thyroid is removed, you may need to take medication after surgery that will do the job of your thyroid gland. This is called thyroid replacement therapy.
Thyroid replacement is typically a pill you take once a day that has the exact same chemical makeup as the hormone your thyroid makes. And you may have to take a pill daily for the rest of your life. Most of the time, people who need thyroid replacement pills start taking them soon after surgery. In fact, you may have been taking them before surgery to try treating your condition.
  • If your entire thyroid is removed, you'll definitely need to begin thyroid replacement therapy.
  • If only half of your thyroid is taken out, you may or may not need to take medication.
TSH test
It may take a little while before the hormone level in your system is right. So about 6 weeks after surgery you'll have a simple blood test called a thyroid-stimulating hormone (TSH) test.
A TSH test lets your doctor figure out how much thyroid medicine you need by seeing if there's too much or too little TSH in your blood. If your dosage is adjusted, your blood will be tested again in another 6 to 8 weeks to see if your TSH is balanced. If it is, you're getting the right amount of thyroid medication.
It may take a few adjustments before the hormone level is balanced. But once it is, you'll most likely have a TSH test once a year. With balanced hormone levels, you shouldn't have any problems with weight gain or low energy, but if you have questions about this ask your doctor.

Risks and Benefits

Benefits
How this surgery benefits you depends on your condition.
  • A thyroidectomy usually works to cure conditions like nodules, goiters, or hyperthyroidism.
  • If you have thyroid cancer, this operation may be enough to cure it. Or it could be an important first step in treating your condition and finding out how advanced the cancer is (or the cancer's stage). And your doctor can decide whether other treatments need to be done afterward.
Risks
Like any operation, a thyroidectomy has some risks. Below are some of the risks of this operation, but this isn't meant to scare you. Understanding what's involved is an important part of any operation. If you have any questions about how these risks relate to you, please ask your doctor. Also, there are some very unusual risks that will not be covered here. So please do not consider this list complete.
There is a risk of injury to the nerves that control your vocal cords. An injury may cause a hoarse-sounding voice, trouble swallowing, or trouble breathing. Any problems may go away in the weeks after surgery, but sometimes they can be permanent.
Because your surgeon needs to work very close to the nerves that control your vocal cords, there's a risk a nerve in this area could be stretched or injured. This may cause a weak or hoarse-sounding voice. You also may not be able to project your voice as well, or hit high notes when you sing. Sometimes, it may be harder to swallow food, drink, or pills. And although seriuos breathing problems are rare, sometimes people get short of breath, have noisy breathing, or trouble coughing. So keep your doctor up to date. She may suggest other procedures to help with any problems. And of course, if you have serious trouble breathing, get emergency help right away. Most of the time, these problems are temporary and go away within 6 months. But in some cases, these problems can be permanent.
There is a risk that the parathyroid glands may be injured or removed during the operation. In some cases, you may need to take calcium pills (possibly every day) for the rest of your life.
Even though the goal of this surgery is to remove all or part of the thyroid gland, there is a risk that the parathyroid glands (which control calcium levels in your blood) may be removed as well. Or they may be injured. The parathyroid glands are very small, and are often difficult for the surgeon to see. So if the parathyroid glands are removed or injured, calcium in your blood may drop to a low level.
If this happens, it may cause:
  • Numbness around your mouth
  • Tingling in your fingers, toes, or lips
  • Muscle twitches or cramping in your feet, hands, or face
If calcium levels are low after surgery, it's usually temporary and can be treated with high doses of vitamin D and calcium medication. But in very rare cases, you may need to take daily medication for the rest of your life.
There is a risk of bleeding both during and after surgery. In rare cases, another operation may be needed to treat any bleeding.
With any surgery, there's a risk of bleeding. Most of the time, your doctor will be able to control any bleeding or it will stop on its own. But bleeding may not happen until several hours, or even days, afterward. If you have bleeding in the days after surgery, in very rare cases, you may need another operation to treat it.
It's common for a small amount of blood and other fluid to collect where the thyroid was removed. But sometimes a lot of blood can collect under the skin, and a hematoma can form. Hematomas are usually small and the body just absorbs them naturally. But in rare cases, a hematoma can be large and may block your airway. If this happens, you may have trouble breathing and you should call your doctor right away. Your doctor may need to drain the area, possibly with another operation.
There is a risk of bad or allergic reactions to the anesthesia, medications, or materials that are used. While it's very rare, you can die from a serious reaction.
Some people may have bad reactions to anesthesia. For example, they may feel sick to their stomach or throw up after their procedure.
But an allergic reaction happens when your body tries to get rid of something it doesn't want. And it's your body's response that can be serious. Signs can include:
  • Dizziness
  • Swelling
  • A rash
  • Trouble breathing
You should know that your healthcare team is trained and ready to respond to allergic reactions. But in rare cases, people can die. If you have ever had an allergic reaction, or know you are allergic to any drugs, foods, or materials (like latex), please let your doctors know. And let them know if you or anyone in your family has ever had a serious reaction to anesthesia.
If surgery is done to treat thyroid cancer, there is a risk that this operation will NOT cure it.
Even if the operation goes exactly as planned, there is a risk that cancer cells may still be in the body after surgery. Removing the thyroid gland often cures many kinds of thyroid cancer. But if cancer cells are still in the body after the operation, other treatments like radioactive iodine treatments may be done. In rare cases, chemotherapy may be needed after the operation.
If surgery is done to treat thyroid cancer, there is a risk that cancer can return after the operation. If this happens, you'll need more thyroid cancer treatments.
Your surgeon will do everything she can to remove all of the cancer. And even though it's uncommon, there is a risk that cancer will return (recur) sometime after surgery. If cancer returns, it can show up where the thyroid gland was, or in the lymph nodes. But very rarely, cancer can spread to other parts of the body like the lungs or bones. If cancer returns, you'll talk with your doctor about the best treatment plan for you. And this may include another operation.
There is a risk of infection. In rare cases, more surgery may be needed to treat an infection.
Although your surgeon will take great care to prevent it, you may get an infection in the area surgery as done, or in other parts of your body (like in your lungs or bladder). Signs of a wound infection include:
  • Redness
  • Swelling
  • Fluid draining from the area surgery was done
  • Pain that gets worse
  • High fever or chills
If you feel any of these things, please call your surgeon right away. Most of the time, antibiotics alone can get rid of an infection. But in some cases, you may need to be admitted to the hospital for surgery or other treatments.
There is a risk of blood clots that, in rare cases, can be life threatening.
Blood clots can form in your blood vessels during or after surgery. In rare cases, a blood clot can travel to the heart or lungs. This can be very dangerous and can even be life threatening. Signs of blood clots include:
  • Sudden shortness of breath
  • Severe chest pain
  • Pain, redness, or swelling in one or both of your legs
If you have any of these signs, call your surgeon or get emergency help right away.
There is an extremely small risk of a stroke, heart attack, or death.
Although the risk of a stroke, heart attack, or death is extremely small, these and other risks are possible during your surgery or recovery. Things like your age, the condition of your heart, being very overweight, and past illnesses and surgeries can make the operation more difficult. As a result, you could become seriously ill or die.

Alternatives

The decision to have a thyroidectomy is up to you.
Thyroid cancerIf you've been diagnosed with thyroid cancer, a thyroidectomy is the only way to treat, or begin treating, your condition.
Watchful waiting for harmless nodules or goiters
For harmless nodules or goiters that don't cause problems, treatment isn't always done right away. This is called watchful waiting. Watchful waiting does NOT mean you or your doctor ignore your condition. Instead, physical exams or ultrasounds are done to keep a close eye on the nodule or goiter to see if it gets bigger or causes other problems. And if your condition becomes more serious later on, you and your doctor will decide if a thyroidectomy or other treatments are needed.
Other treatments
Other conditions like hyperthyroidism can often be treated with things like medication and radioactive iodine treatments.  You may have even tried them and they didn't work. But most likely, you've at least talked with your doctor about these treatments already and decided that surgery is right for you.
This operation often works to treat, or begin treating, many thyroid conditions. And again, even though your body needs thyroid hormone to work well, there is medication to replace it. So even if your entire thyroid gland is removed, you can live a normal, healthy life.

Health Information Forms

After you print this summary, you can fill out the following forms. Keep a copy at home and take a copy to your next doctor's appointment.
DISCLAIMER
Emmi is an interactive, informational program offered by doctors to educate patients about risks, benefits, and potential outcomes associated with various medical treatments and surgical procedures. Your doctor has chosen to use Emmi to help you understand a health care procedure that he/she has recommended. To ensure that your doctor knows that you viewed this presentation, a record of your viewing will be sent to him or her as part of the informed consent process. By participating in this program, you are agreeing to allow Emmi to share the information you have provided to Emmi with your doctor. Emmi is provided for information and education purposes only. No doctor/patient relationship is established by your use of this program. Emmi provides no specific diagnosis or treatment for you. The information contained here is an educational supplement to your consultation with your doctor. While Emmi is intended to educate you about the procedure your doctor has recommended and the most common potential risks and complications of the procedure, it is not all-inclusive. There may be other complications, known and unknown, which result from the surgery. No guarantees or warranties are made regarding the surgery itself. Emmi is not intended to offer specific medical or surgical advice to anyone. It is also not a substitute for the informed consent process that your doctor will handle directly with you. Further, please be sure to discuss any questions or concerns you have regarding the information contained here, as well as the risks associated with refusing the treatment or procedure, directly with your doctor.
By participating in this program, you are agreeing to allow Emmi to share the information you have provided to Emmi with your doctor.
©2011, Emmi Solutions, LLC. All rights reserved.

2013年12月29日星期日

Free T guide post Thyroidectomy

What are T4 and T3?

T3 is the active thyroid hormone utilized in the body. The thyroid makes very roughly 20% of the T3 in the body though some people it likely makes way more than this amount. This is the portion that is not converted from T4. The rest of the active T3 comes from conversion from T4, this occurs in many places in the body though many places depend upon the liver and other places to convert it for them. The thyroid makes other things too, but mainly T4 or the storage thyroid hormone. T4 cannot be used anywhere in the body so it is considered inactive or storage only. It can only be converted to active hormone before being used. This is kind of like crude oil which isn't gasoline, and crude oil doesn't fire in the cylinders of the car, only gasoline does but of course we do need crude oil to get gasoline (called refining not conversion). 

After thyroidectomy most doctors give T4 only despite knowing the thyroid made more than T4. 

T3 is in a prescription called cytomel, this is synthetic T3. Cytomel is often sold in 5 mcg (low amount) or 25 mcg (high amount) pill forms so it is difficult to titrate a long term dosage. T3 is also in natural thyroid prescriptions (from animals). There are 9 mcg of T3 in each grain of natural thyroid. T3 has very rapid effects.

T4 is in a prescription called Levothyroxine, Synthroid, Tirosint and other names. These are the synthetic forms. It also is in natural thyroid prescriptions (from animals). In natural thyroid there are 38 mcg of T4 per grain of natural thyroid. T4 tends to change things slowly.

Animal based thyroid hormones do contain thyroglobulin (Tg) as a binding agent, this can make it past the digestive system to the bloodstream. Tg is the lab based cancer marker used for checking for cancer recurrence after TT, and a rising Tg (at similar TSH) is indicative of cancer recurrence. For the accuracy of cancer screening your Tg lab is then dependent upon your digestive system staying the same over time which is unlikely, if getting a Tg lab one might have to swap in synthetic (T4 and T3 if you like) for up to 30 days ahead if considering natural thyroid.

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General info on Free T’s (laboratory test):

One learns that Free t's, not TSH are the most critical thing to feeling well. It's not that we ignore TSH, because that is important for cancer prevention but TSH does not help you feel well. Free t's should be your guide to feeling well. Most doctors don't bother checking Free T labs carefully, they just look at TSH and assume you are ok even though the Free t's may be super out of whack and unfortunately you will be too.

One also has to look at vitamins, minerals, cortisol, iron, B-12, and others. Importantly, if T3 levels are good and Free t4 not too high that is a very important signal to look at reverse T3 and related issues such as iron.

Free t ranges are in a state of change. Free t4 ranges coming down, Free T3 ranges coming up over last 5 years. Ranges were designed around people with a thyroid, we need higher Free T3 post TT because we no longer have an on demand system and generally speaking the pituitary makes its own T3 from T4 so we want to be sure the rest of the body has an adequate supply in the post TT world where T3 issues cause most of the problems that happen because doctors take the T4 high making the pituitary supplied but the rest of the body not.

Because I use that as a method, I reference people carefully doing Free T labs at about midpoint from thyroid meds. Midpoint is not close to taking medications, and not too far from medications.

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Two common problem areas and some symptoms

High Free t4 – symptoms include mood changes and swings, irritability or a short temper, headache and migraine, body aches and pains

Low Free t3 – all the symptoms of hypothyroidism, but common are the brain fog or loss of attention span, feeling tired or no ability to do things like we used to, skin issues, hair loss, fingernail issues, inability to lose weight despite honest effort, and many more

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FREE T3 – Active hormone
A better Free t3 range in US (traditional units) post TT would be something like 3.0 to 5.0 pg/mL (roughly 20% added to a normal thyroid patient). One can get Free T3 related hypo symptoms well into the mid 3's particularly with no thyroid. If you are generally above 3.0 pg/mL and have no other issues such as vitamin, mineral, adrenal/cortisol and sex hormone related it is possible to feel ok. Official ranges vary but often much lower, an example range semi-updated would look like 2.4 to 4.4 pg/mL, but I would love to see the bottom raised. Definitely aim for above 3.0 pg/mL, and if you can get to 4.0 pg/mL that is better. Generally speaking if one optimizes all issues such as vitamin and mineral and other mentioned above, and the FT3 is low the only way to raise it is a long term cytomel prescription or natural thyroid containing T3.

For system international (SI) including Canada, or mostly non-US based labs: Conversion factor pg/mL to pmol/L is 1.5362. SI free t3 ranges, a suggested better range post TT as 4.5 to 7.5 pmol/L. Aim for a minimum of 4.5 but 6.0 pmol/L is better.

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FREE T4 – storage hormone only no merit to making it high.
Older Free t4 ranges in US often went as high as 2.0 ng/L but some places have taken the top down to 1.5 ng/L now, and if not that then maybe 1.7 or 1.8 ng/L. I don't like my Free t4 over 1.4 so I can let T3 do its job. I am fine at moderate Free t4, or 1.1 or 1.2 ng/L but people vary where they feel well and some like it a bit higher. If I had lots of Reverse T3 I would let my Free t4 go much lower because reverse T3 is made from T4. An example range reasonably updated would look like 0.75 to 1.5 ng/L. If you test above 1.4 the only way to reduce this number is to reduce your T4 medications, and if your TSH is not where needed you need a long term cytomel prescription or switch to natural thyroid.

For system international (SI) or non-US ranges: Conversion factor ng/L to pmol/L is 12.87. For SI look for ranges ending somewhere around 19.0 pmol/L but stay under that. Ranges might run 9.6 to 19.0 pmol/L. I personally would like my FT4 level about 15.0 if it were in SI ranges.

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Important lab based goals and supplements to discuss with your doctors: 

Total Vitamin D (25-Hydroxyvitamin D): 70 ng/mL 
B-12: 800 pg/mL 
Ferritin male over 100 ng/mL, female 90 ng/mL but ferritin is just storage iron or one type of iron measure

One can take Selenium and Zinc to help the T4 convert to T3. Check all your vitamins before adding as you do not want to go too high. Suggested dose:
Selenium up to 200 mcg OR several Brazil nuts
Zinc 30 mg

Iodine 300 to 500 mcg a day

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When to get Free t labs: 

If you test soon after taking your thyroid meds the levels on Free t’s will read too high, if you test the next morning before you take meds it might be too far out and will test low. I suggest a minimum of four hours but best perhaps at 9 to 12 hours out from taking thyroid medications, or the midpoint. Whatever you choose a consistent method not too close and not too far from taking your medications should be used to see if things are moving the right direction.

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Where to get Free t labs: 

If docs won’t order, first look for a doc that does, but you can order your own:

Posted by reneeh63
http://www.healthonelabs.com/pub/tests/test/pid/167

There is also mymedlab.com :
https://www.mymedlab.com/thyroid/thyroid-basic-panel

Canary Club which is great for cortisol and others, their thyroid labs use blood spot and gives somewhat differing results than LabCorp for example:
http://www.canaryclub.org/

----------
My doc doesn't want any of this, what should I do?

You can always look for another doctor, in the mean time all the issues mentioned under supplements and lab based goals section can be worked on with a primary care. 

You can also switch around the T4's. Tirosint is perhaps the best T4 out there because it does not have the fillers that many get issues with in other T4's. There have been people who posted taking exact same amount (mcg the same) of synthroid and Tirosint yet the results for Free t3 improved on the Tirosint meaning the conversion was improved. So it is a good first choice to try to help improve things, but it may not always improve T3 for all people just certain ones. I have less side effects on Tirosint versus synthroid, but I need plenty of cytomel on either. Nevertheless, Tirosint many docs will give a prescription for, cytomel many docs won't, and since it can often help out it is a good start.

Your dose may need to lower on Tirosint since it is highly absorbed and Tirosint may cost you a lot more. You can try other T4's too. If nothing else most doctors would certainly agree to try these T4 options.

----
But my endocrinologist said my numbers look "good"?

What an endocrinologist means when they say something like numbers are "good", means you are TSH suppressed for cancer recurrence prevention. TSH does NOT help you feel well, it has nothing to do with that. To feel well a person has to look at carefully timed Free T levels, plus vitamins, minerals, etc. 

It is possible to have both cancer recurrence prevention and to feel well via well adjusted and timed Free T labs, vitamins, minerals, but don't expect that many an endocrinologist to do that for you though some might. The main lesson is you will have to be your own advocate and take your own initiatives, make your own requests. For the most part the vitamin, mineral and sometimes even the Free T's have to be worked out via your request and initiative with a primary care and sometimes a general endocrinologist can take over once the Free T level are adjusted properly. 

Endocrinologists are paid to handle cancer recurrence prevention, not help you adjust Free T's, vitamins and minerals like iron or others. Some will do this free of charge essentially but don't expect lots for free. This is the mandate of the terrible insurance system in the USA. Though insurance varies, endocrinologists are paid for what medicare coding dictates and that relates to TSH suppression and checking for cancer. Other countries often just copy what the USA does even though medicare coding is a flawed system. None of that will help you feel well, though it may help you prevent cancer from coming back plus detecting it if it does starts coming back. Most people post thyroidectomy still do need the traditional care of looking at cancer recurrence.
=================

T3 supplement and FAQ’s, an addition to the Free T guide

T3 supplement and FAQ’s, an addition to the Free T guide

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How do I add cytomel to my T4 prescription?

To keep things roughly the same TSH reduce t4 by 4 mcg for each 1 mcg of T3 added. That is rough, and people vary all over but it is always easy to add T4 back so I would reduce the T4 prescription by 4 mcg for each 1 mcg T3 added first.

For safety sake, if the TSH is already very low on T4 meds you should remove the T4 well ahead, such as a week before adding the T3 you plan on trying.

People needing larger amount of T3 often need to bring the amounts up slowly over time.

-----

How do I take T3?

Many people divide in two and take half of the daily dose first thing in AM and half in afternoon. That is to help with T3 run-out. If you take it once a day your alertness levels will swing too much.

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Can I take cytomel with food?

I would not take natural thyroid with food, but sometimes cytomel is taken with food by some people. So the food issue is complex. Basically yes you can take it with food, somewhat.... That varies all over and is person specific.

A few people can't take it with food at all or it does not absorb.

Other people do take T3 with light food to slow down the T3 rate, this is hard to understand until you understand what T3 run-out is, but taking it with food slows that down sometimes for some people. Taking it on an empty stomach and sometimes it gets "used up" too quickly or you are subject to T3 run-out.

So the answer is all over.

Just keep in mind once on any T3 for the long term, that Free t testing has to be done much more carefully timed than before being on anything with T3.

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Does T3 help me lose weight?

The way I describe cytomel and weight is, if you do a super hard diet and your T3 levels are poor you will fail. If you do a super hard diet and T3 levels are good you have a chance. But the super hard diet makes you lose weight; the T3 level if poor prevents it from working but does not cause weight loss as that is the role of the diet.

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Does T3 swing TSH around with lots of daily variation as I was told it will and I need my TSH suppressed due to thyroid cancer?

No. You can get what is called T3 run-out where the T3 gives a high alertness level after you take it and this often will fade as one gets to the afternoon, but the TSH would probably not change. Missing a T3 dose can cause the TSH to change small amounts. In my experience dropping a cytomel dose for a day only changed my TSH by 0.2 (from 0.1 to 0.3).

----

I switched to natural thyroid for my T3, can this change my Thyrogobulin (cancer marker)?

Animal based thyroid hormones do contain thyroglobulin (Tg) as a binding agent, this can make it past the digestive system to the bloodstream. Tg is the lab based cancer marker used for checking for cancer recurrence after TT, and a rising Tg (at similar TSH) is indicative of cancer recurrence. For the accuracy of cancer screening your Tg lab is then dependent upon your digestive system staying the same over time which is unlikely, if getting a Tg lab one might have to swap in synthetic (T4 and T3 if you like) for up to 30 days ahead if considering natural thyroid.

-----

Does T3 cause a-fib, irregular rhythm and heart rate problems?

TSH being highly suppressed is what generally might cause you to get a-fib, irregular rhythm and heart rate increases. Adding T3, which highly and quickly changes TSH, just has to be done with way more care that's all. Since both T4 and T3 both change TSH they both can cause these issues. It is just that one has to be done more carefully than the other one. T4 is slow to act, T3 changes things almost immediately. When they both cause TSH changes it is easier to just use T4 since it is slow to act, but does not mean T3 can't be used any more than T4.

Another major factor on these issues is cortisol levels (adrenal hormone). People with low or high cortisol levels, even if only subclinically low or high, are more subject to irregular rhythm and heart rate problems. Correcting cortisol levels can often help for those with these issues.

-----

When I add T3 to my regimen the TSH is so suppressed, why is this?

You may need to drop some T4 done after checking Free t levels, however most with good moderate Free t levels may have TSH/pituitary errors. Some of the TSH error sources are discussed on the National Association of Hypothyroidism website.

http://nahypothyroidism.org/

The pituitary is a feedback control system that wasn’t really designed around people doing thyroid cancer recurrence prevention and may not normally operate under these conditions.

The pituitary makes its own T3 supply from T4 via direct conversion for its own use though it measures the total thyroid hormone levels in the bloodstream it does not depend on the blood T3 levels apparently since it can convert its own supply. This often results in peripheral signs of hypothyroidism such as skin or hair issue even though TSH is suppressed.

Reverse T3 (rT3) counts against TSH yet supplies no benefit since even rT3 is a hormone that is measured as part of the total hormone level by the pituitary

In general the worse a T4 to T3 converter you are the less reliable your TSH reading may actually be.

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Links to more info?

Easy graphic - posted by MtDenali on this list:
http://www.thehealthyhomeeconomist.com/thyroid-disease-as-a-psychiatric-pre tender/

Dr Mercola on using Free t’s instead of TSH as primary labs (Dr Mercola is not addressing thyroid cancer patients but lays out case for Free t's):
http://www.mercola.com/article/hypothyroid/diagnosis_comp.htm

Posted by silverem
http://www.dearpharmacist.com/2013/01/29/how-you-measure-thyroid-hormone-it -matters/

Thyroid help - general

NAH – National Association of Hypothyroidism - great graphics.

http://nahypothyroidism.org/

Dr Holtorf related links

http://www.holtorfmed.com/

http://www.hormoneandlongevitycenter.com/thyroidtreatments1/

Mary Shomon – outstanding author

http://thyroid.about.com/

Dr Shames related – one of original authors on more than just T4

http://thyroidpower.com/

T4 to T3 really good summary:
http://www.naturalendocrinesolutions.com/articles/do-you-have-a-t4-to-t3-co nversion-problem/

Reverse T3 links

http://thyroid.about.com/od/t3treatment/a/Reverse-T3-triiodothyronine-RT3-T hyroid.htm

http://health.groups.yahoo.com/group/RT3_T3/

http://www.custommedicine.com.au/health-articles/reverse-t3-dominance/


Order your own labs!!

Posted by reneeh63
http://www.healthonelabs.com/pub/tests/test/pid/167

There is also mymedlab.com :
https://www.mymedlab.com/thyroid/thyroid-basic-panel

Canary Club which is great for cortisol and others, their thyroid labs use blood spot and gives somewhat differing results than LabCorp for example:
http://www.canaryclub.org/


Links to doctors that may help

http://thyroid.about.com/cs/doctors/a/topdocs.htm

Some osteopathic physicians will look more into T3 and T4, some but not all
http://www.osteopathic.org/osteopathic-health/Pages/find-a-do-search.aspx

Naturopaths in some states can give prescriptions, select Adrenal/endocrinology disorders and enter zip code
http://www.naturopathic.org/AF_MemberDirectory.asp?version=2